Merck Patent Gmbh

Merck Patent Gesellschaft

Merck Gmbh

Christopher Barnes

Johannes Gleitz

Dieter Dorsch

Christos Tsaklakidis

Werner Mederski

Bertram Cezanne

Wolfgang Strittmatter

Uwe Hofmann

Matthias Frech

Horst Juraszyk

Johannes Gleiltz

Wrner Mederski

Novel compounds of the formula (I), in which D, W, X, Y, T and Rare as defined in Patent Claim, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.

Phenyl derivatives as factor XA inhibitors

Novel compounds of the formula I in which

Benzimidazole derivatives

The present invention relates to the polypeptide Saratin and its use for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation after vascular injuries or endarterectomy. The invention furthermore relates to a novel medical use of Saratin as an inhibitor of thrombosis and intimal hyperplasia, where the Saratin polypeptide may be used locally as a topical agent or as a coating on, or otherwise incorporated or associated with medical devices or vascular grafts.

Specific mechanism for inhibiting platelet adhesion to collagen

Novel compounds of the formula I in which W, X, Y, T, Rand Rare as defined in Patent claim, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders 

Phenyl derivatives

Novel compounds of formula (I), wherein D, W, X, Y, T and Rhave the meanings cited in claim, are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors 

Derivatives of phenoxy-n-'4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors

Novel compounds of the formula I in whichD, W, X, Y, T and Rare as defined in Patent Claimare inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.

Carboxylic acid amides

Novel compounds of the formula I in which X, Y, Z, R, R, Rand Rare as defined in Patent Claim, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of tromboembolic diseases and for the treatment of tumors

Biurethane derivatives

Use of the polypeptide Saratin for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation after vascular injuries or endarterectomy. The invention furthermore relates to a novel medical use of Saratin as an inhibitor of thrombosis and intimal hyperplasia, wherein the Saratin polypeptide may be used locally as a topical agent or as a coating on, or otherwise incorporated or associated with medical devices.

Saratin for inhibiting platelet adhesion to collagen

The invention relates to semicarbazides of the general formula Iwhere R, R, R, Rand I have the meaning indicated in claim The compounds of the formula I can be employed as pharmaceutical active compounds in human and veterinary medicine, in particular for the control and prevention of thromboembolic disorders such as thrombosis, mycocardial infarct, arteriosclerosis, inflammation, apoplexy, angina pectoris, restenosis after angioplasty and intermittent claudication.

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Bad Soden, Germany

Christopher Barnes