The United States of America, As Represented by the Secretary, Department of Health and Human Services

Montana State University

Christopher Barbour

Bibiana Bielekova

Mika Komori

Mark C Greenwood

Peter Kosa

A tool for use in installing and removing a cleco fastener. The tool includes a main body of the tool. The main body defines an elongated length. A grip pocket radially extends from the main body and is configured for receiving a shoulder extending from a cylindrical body of the cleco. A pusher surface is spaced-apart along the length of the main body from the grip pocket and also radially extends outwardly of the main body and configured for pushing a plunger extending from the cylinder body of the cleco. The pusher surface is configured for slidable movement along a portion of the length of main body. A handle is slidably received within the main body and coupled with the pusher surface to provide translation to the pusher surface to engage the plunger of the cleco to activate the cleco.

Tool and associated method for temporary fastener placement

Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described. Methods of treating subject with neurological disease, and methods of evaluating the efficacy of particular treatments, based on detection of the disclosed biomarkers are also described.

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Bozeman, MT, United States of America

Christopher Barbour