Saint Louis University

Government of the United States of America, As Represented by the Secretary of Commerce

Christopher Arnatt

Ryan D McCulla

Ankita Isor

Daniela Salvemini

John T Petroff, Ii

John Elliott

Chelsea DeLeon

In one aspect, the present disclosure provides a compound of the formula: In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.

Photoswitchable dibenzothienylmethyl triphenylphosphonium derivatives and methods of treating cancer therewith

In one aspect, the present disclosure provides compounds of the formula (I): In other aspects, the present disclosure provides compositions and methods of targeting GPER for the treatment of cancers, such as breast cancers and leukemias, gallstone disease, cardiovascular disease, and for conferring of neuroprotection on a subject. Also disclosed are high throughput assays for identifying antagonists of GPER.

Compounds and methods targeting GPER for treatment of diseases associated with calcium

Disclosed herein are compositions and methods for treating neuropathic pain in a subject in need thereof. Compositions disclosed herein are GPR183 antagonists. The methods include administering to a subject in need thereof a therapeutically effective amount of a GPR183 antagonist.

GPR183 antagonists for the treatment of pain

In one aspect, the present disclosure provides a compound of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.

Dibenzothiophene derivatives and methods of treating cancer therewith

The present disclosure provides compositions and method targeting GPER for the treatment of cancers, such as breast cancers and leukemias, gallstone disease, and for conferring of neuroprotection on a subject. Also disclosed are high throughput assays for identifying antagonists of GPER.

Compounds and methods targeting GPER in calcium disorders

The present invention generally relates to various dibenzothiophene compounds, processes for preparing these compounds, and use of these compounds in organic light-emitting diodes and as cellular imaging agents. In particular, the compounds of the present invention include various sulfoxide and sulfone analogs of various dibenzothiophene compounds. The present invention also relates to cell imaging agents comprising one or more of the dibenzothiophene compounds and processes for imaging a cell using the compounds. The present invention also relates to organic light-emitting diodes comprising one or more of the dibenzothiophene compounds and processes for preparing these organic light-emitting diodes.

Dibenzothiophene compounds

The present invention relates to a process for making an asymmetric fluorophore. The asymmetric fluorophore is useful as a stain for staining live cells or fixed cell and provides whole-cell staining of such cells.

Growing community of inventors

Kirkwood, MO, United States of America

Christopher Arnatt