Cambridge Enterprise Limited

Hoechst Schering Agrevo Gmbh

Ionscope Ltd

Astex Technology Limited

Christopher Abell

Roger Coulston

Oren Scherman

Jing Zhang

Xin Li

Clive Adrian Smith

David Klenerman

Carol Robinson

Wilhelm T S Huck

Ulrich Genschel

Frank Von Delft

Tom L Blundell

Bernd Laber

Ziyi Yu

Alison Gail Smith

Yuri Engenievich Korchev

Timothy Sharpe

Todd Mize

Richard Parker

Liming Ying

Andreas Bruckbauer

Oren Alexander Scherman

Wilhelm TS Huck

A nested capsule having a first capsule held within a second capsule. Each of the first and second capsules has a shell that is a supramolecular cross-linked network, such as a cucurbituril supramolecular cross-linked network. Each capsule shell is obtained or is obtainable from the complexation of a composition including a host, such as cucurbituril, and one or more building blocks having suitable guest functionality for the host, thereby to form a supramolecular cross-linked network. The nested capsules are suitable for delivering and selectively releasing an encapsulant at a location.

Nested supramolecular capsules

Systems that employ microdroplets are used in embodiments for Microdroplet Electrospray Ionisation Mass Spectrometry (ESI MS). Thus, a method of detecting an analyte includes providing an oil composition comprising oil and an aqueous microdroplet comprising the analyte, the oil composition comprising a surfactant to stabilise the aqueous microdroplet in the oil composition; and performing ionisation mass spectrometry analysis of the oil composition.

Microdroplet ionisation mass spectrometry

Provided is a capsule having a shell of material that is a supramolecular cross-linked network. The network is formed from a host-guest complexation of cucurbituril (the host) and one or more building blocks comprising suitable guest functionality. The complex non-covalently crosslinks the building block and/or non-covalently links the building block to another building block thereby forming the supramolecular cross-linked network. The capsules are obtained or obtainable by the complexation of a composition comprising cucurbituril and one or more building blocks having suitable cucurbituril guest functionality thereby to form a supramolecular cross-linked network.

Supramolecular capsules

The subject invention pertains to a method for the production of an array of molecules immobilised on a substrate, comprising the deposition of the molecules from a micropipette containing them, onto the substrate, in a liquid environment, wherein the distance of the micropipette from the substrate is controlled in response to the ion current in the liquid. This method is particularly suitable for the deposition of biological molecules. The subject invention also pertains to an array of biological molecules deposited on a substrate.

Production of molecular arrays

Herbicides test method

A crystal of pantothenate synthetase (PS) has a monoclinic space group P2 and unit cell dimensions of a&equals;66.0&plusmn;0.2 &angst;, b&equals;78.1&plusmn;0.2 &angst;, c&equals;77.1&plusmn;0.2 &angst; and &bgr;&equals;103.7&plusmn;0.2&deg;.

Crystal structure

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Cambridge, United Kingdom

Christopher Abell