Princeton University

Christopher A Traina

Jeffrey J Schwartz

Thomas Joseph Dennes

Oxide, oxysulfide, or phosphate host particles with a self-assembled organo-phosphonate monolayer covalently bonded thereto are disclosed. Methods for coating the host particles and use of rare earth ion-doped particles in imaging methods and photodynamic therapy methods are also disclosed.

Nano-particle surface modification

Nanoparticles are functionalized for use as bio-imaging probes using a novel, modular approach. Particle surface modification is based on a phosphonate monolayer platform on which was built a multi-segmented, multi-functional film: the first segment provided hydrolytic stability, the second aqueous suspendability, and the third, selectivity for cell attachment. In vitro imaging experiments visualized nanoparticle-cell surface binding. Peptide-derivatized nano-particles were not displaced from cells by soluble peptide. Methods for coating the host particles and use of rare earth ion-doped particles in imaging methods and photodynamic therapy methods are also disclosed.

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Napa, CA, United States of America

Christopher A Traina