May & Baker, Ltd.

Christopher A Ramsden

Philip Knowles

Edward Lunt

Peter J Warne

Libert C Saunders

Raymond F Collins

Derek E Wright

Edward J Lewis

3-(N,N-Dimethylcarbamoyl)pyrazolo[1,5-a]pyridine of the formula: ##STR1## which is a new compound, possesses pharmacological properties, in particular properties which are indicative of outstanding utility in the treatment of arthritic disorders such as rheumatoid arthritis. The compound can be prepared by reacting a pyrazolo[1,5-a]pyridine-3-carbonyl halide (e.g. chloride) with dimethylamine.

Treating arthritis with 3-(N,N-dimethyl carbamoyl)pyrazolo[1,5-a]pyridine

New tetrazole derivatives of the general formula: ##STR1## [wherein R.sup.1 represents a halogen atom, a straight- or branched-chain alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino, or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), a straight- or branched-chain alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl or alkanoylamino group containing from 2 to 6 carbon atoms, a cycloalkylcarbonyl group containing from 3 to 8 carbon atoms in the cycloalkyl moiety, or a hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl or aroyl group, or a group of the formula:

2'Hydroxy tetrazole-5-carboxanilides and anti-allergic use thereof

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Brentwood, United Kingdom

Christopher A Ramsden