Case Western Reserve University

Other

Kent State University

Christopher A Flask

Jeffrey L Duerk

Jonathan S Lewin

James P Basilion

Daniel Robert Elgort

Eddy Y Wong

Songping D Huang

Jihua Hao

Yongxiu Li

Gheorghe D Mateescu

Ken Pin Wang

A method of diagnosing a mitochondrial related disease in a subject includes administering a deuterated metabolic water precursor to the subject, measuring a rate of deuterated water formation in a sample region of the subject, and comparing the measured deuterated water formation in the sample region to a control value. A difference between the rate of deuterated water formation in the sample region compared to a control value is indicative of a mitochondrial related disease.

Deuterated metabolic water precursor for detecting and treating diseased tissue

A new and improved method for tracking and/or spatial localization of an invasive device in Magnetic Resonance Imaging (MRI) is provided. The invention includes providing an invasive device including a marker having a chemically shifted signal source with a resonant frequency different from the chemical species of the subject to be imaged, applying a pulse sequence, detecting the resulting RF magnetic resonance signals, and determining the 3D coordinates of the marker. The invention also includes generating scan planes and reconstructing an image from the detected signals to generate an image having the marker contrasted from the subject. The invasive device includes a marker having a chemically shifted signal source which has a resonant frequency different from the chemical species of the subject to be imaged for use in tracking the device during imaging.

Chemical shift markers for improved wireless fiducial marker tracking

An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.

Nanoparticles based on gadolinium coordination polymers as highly sensitive T1 MRI contrast agents

Growing community of inventors

Avon Lake, OH, United States of America

Christopher A Flask