Cytometrics, Inc.

Cytoprop, L.l.c.

Christopher A Cook

Mark M Meyers

Warren Groner

Richard G Nadeau

An in vivo imaging device having an illumination system that creates a virtual source within a tissue region of a subject in a non-invasive manner. The illumination system transforms a maximum amount of illumination energy from a light source into a high contrast illumination pattern. The illumination pattern is projected onto the object plane in a manner that maximizes the depth to which clear images of sub-surface features can be obtained. The high intensity portion of the illumination pattern is directed onto the object plane outside the field of view of an image capturing device that detects the image. In this configuration, scattered light from within the tissue region interacts with the object being imaged. This illumination technique provides for a high contrast image of sub-surface phenomena such as vein structure, blood flow within veins, gland structure, etc.

Method and apparatus for providing high contrast imaging

The invention comprises a system and method of calibrating a reflected spectral imaging apparatus used for analysis of living tissue. In addition to the reflected spectral imaging apparatus itself, the calibration apparatus comprises an optical filter that is placed between the light source used in the imaging apparatus and the object under analysis, and a calibration module. The filter is fabricated such that when the light is passed through the filter, an image is projected onto the focal plane where imaging is to take place within the object. The image projected by the filter comprises a plurality of areas, each having a different known optical density. For each area, the calibration module measures the intensity of the light reflected from the area and maps the light intensity measurement to the optical density known to be present at the area. This correspondence of light intensity measurements and known optical densities is then used to calibrate the reflected spectral imaging apparatus.

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Philadelphia, PA, United States of America

Christopher A Cook