Université De Limoges

Centre National De La Recherche Scientifique

Centre National De La Recherche Scientifique-Cnrs

Laboratoire Francais Du Fractionnement Et Des Biotechnologies

Christophe Sirac

Christophe De Romeuf

Christine Gaucher

Jean-Claude Brouet

Michel Cogne

Micael Bardel

Catherine Decourt

Caroline Le Morvan

The present invention relates to a chimeric protein comprising at least one human amyloid P component and at least one fragment of an Fc region of a human antibody, the human amyloid P component and the fragment of an Fc region with which it is associated being bound to each other by means of a hinge region.

Chimeric protein in the treatment of amyloidosis

The invention relates to a non-human transgenic mammal with an IgH locus modified by replacement of the switching sequence S&#x3bc; with all or part of a transgene comprising the gene C&#x3b1; of a class A human immunoglobulin, including at least the exon, coding for the CH3 domain and the membrane exon and the applications of the above for the production of humanized class IgA antibodies.

Non-human transgenic mammal for the constant region of the class a human immunoglobulin heavy chain and applications thereof

Growing community of inventors

Limoges, France

Christophe Sirac