Sanofi-a Ventis Deutschland Gmbh

Christophe Salagnad

Frank Zocher

Paul Habermann

Wolfgang Holla

Sebastian Rissom

Stephane Mutti

Heinrich Decker

Berndt Kulitzscher

Bernd Junker

Thomas Stuedemann

Jochen Hachtel

Christoph Tappertzhofen

Claus-Jügen Maier

Rolf Hoerlein

Oliver Maneg

Claus Lattemann

Laure Landric-Burtin

Laure Landric-Burtain

The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry.

Method for amidating polypeptides with basic amino acid C-terminals by means of specific endoproteases

The invention relates to the production of carboxy-terminal (C-terminal) amidified peptides with C-terminal amidified lysin, in particular with the biological activity of GLP-1, the chemical and/or biotechnological precursors and intermediate products thereof. The invention also relates to a method for the production and use thereof for producing pharmaceutical products.

Method for producing carboxy-terminal-amidified peptides

The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I). wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for peroxisome proliferator-activated receptors (PPAR activators) which are useful in the therapeutic treatment of a number of diseases and disorders of the central nervous system such as multiple sclerosis, Parkinson's Disease, psychiatric disorders and the like. The present invention is a novel process for preparing PPAR activators of the formula (I) which do not have the disadvantages of the processes known in the prior art. In particular, a process is provided with which the PPAR activators of formula (I) can be prepared in a suitable enantiomeric excess, i.e. high enantioselectivity, without the need for subsequent chiral chromatography.

Method for the production of diarylcycloalkyl derivatives

Growing community of inventors

Chatellerault, France

Christophe Salagnad