Societe De Conseils De Recherches Et D'applications Scientifiques Sas

Soci&eacute;t&eacute; De Conseils De Recherches Et D'applications Scientifiques, S.a.s.

Christophe Philippe Moinet

Barry A Morgan

Christophe Thurieau

Thomas D Gordon

Lydie Francine Poitout

Marie-Odile Galcera

Dennis C H Bigg

Jacques Pommier

The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors. 

Imidazolyl derivatives

The present invention is directed to imidazolyl derivatives or pharmaceutically acceptable salts thereof which are useful as agonists or antagonists of somatostatin receptors, having the following formula (I), wherein the substituents are defined in the specification.

The present invention is directed to imidazolyl derivatives of the formula:where the substituents are defined in the specification, or a pharmaceutically acceptable salt thereof. The derivatives bind selectively to the somatostatin subtype receptors and elicit either an agonist or antagonist effect from the somatostatin subtype receptors. The derivatives are useful for treating a variety of diseases including acromegaly, restenosis, Crohn's disease, systemic sclerosis, external and internal pancreatic pseudocysts and ascites, VIPoma, nesidoblastosis, hyperinsulinism, gastrinoma, Zollinger-Ellison Syndrome, diarrhea, AIDS related diarrhea, chemotherapy related diarrhea, scleroderma, Irritable Bowel Syndrome, pancreatitis, small bowel obstruction, gastroesophageal reflux, duodenogastric reflux, Cushing's Syndrome, gonadotropinoma, hyperparathyroidism, Graves' Disease, diabetic neuropathy, Paget's disease, polycystic ovary disease, cancer, cancer cachexia, hypotension, postprandial hypotension, panic attacks, GH secreting adenomas or TSH secreting adenomas.

&bgr;-carboline compounds

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Chatenay Malabry, France

Christophe Philippe Moinet