Sanofi

Christophe Pacaud

Jacques Froissant

Frank Marguet

Frederic Puech

Antoine Ravet

Jean-Francois Gibert

Frédéric Puech

Sylvain Cote Des Combes

Sylvain Cote-Des-Combes

Sylvain Cote-Des Combes

Jean-François Gibert

Larry Davis

Jean-François Gilbert

Compounds corresponding to the general formula (I) wherein Rrepresents a group C-alkyl, C-cycloalkyl, C-cycloalkyl-C-alkyl, C-alkyl-C-cycloalkyl, C-cycloalkyl-C-cycloalkyl, C-alkylthio-C--alkyl, C-alkoxy-C-alkyl, hydroxy-C-alkyl, hydroxy-C-alkyl-C-cycloalkyl-C-alkyl, hydroxy-C-cycloalkyl, C-fluoroalkyl or C-fluorocycloalkyl; an optionally substituted heterocyclic group; a group C-alkyl substituted with an optionally substituted heterocyclic group; Xrepresents a group chosen from hydrogen, fluorine, chlorine and bromine atoms or a group C-alkyl, C-cycloalkyl, C-cycloalkyl-C-alkyl, C-fluoroalkyl or cyano; and Rrepresents an aryl group such as phenyl or naphthyl, optionally substituted with one or more substituents,in the form of the base or of an acid-addition salt, and the therapeutic use thereof.

3,4-dihydropyrrolo[1,2-A]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof for diseases involving casein kinase 1 epsilon and/or casein kinase 1 delta

Compounds corresponding to the general formula (I) 

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The invention relates to 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to the general formula (I) in which Rrepresents an aryl group optionally substituted with one or more halogen atoms or C-alkyl, C-alkyloxy, C-alkylthio, C-fluoroalkyl, C-fluoroalkyloxy and &#x2014;CN groups or Rrepresents a group chosen from C-alkyl, C-fluoroalkyl, C-cycloalkyl or C-cycloalkyl-C-alkyl groups; A represents a C-alkylene group; B represents a C-alkylene group; L represents either a nitrogen atom optionally substituted with an Ror Rgroup, or a carbon atom substituted with an Rgroup and an Rgroup or two Rgroups; the carbon atoms of A and of B being optionally substituted with one or more Rgroups, which may be identical to or different from one another. Preparation process and therapeutic use. 

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Paris, France

Christophe Pacaud