Ucb Pharma Gmbh

Christophe Joseph Szczepaniak

Ralf Kanzler

Alain Merschaert

Joerg Hamann

The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine.

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Brussels, Belgium

Christophe Joseph Szczepaniak