Etablissement Francais Du Sang

Institut National De La Sante Et De La Recherche Medicale

Université De Franche Comte

Centre Hospitalier Universitaire De Besançon

Christophe Ferrand

Marina Deschamps

Carole Henry

Christophe Borg

Pierre-Simon Rohrlich

Pierre Tiberghien

Fabrice Larosa

The present invention is relative to an isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antibody or antibody fragment which includes a anti-IL-1RAP binding domain, polypeptides encoded by this nucleic acid molecule, isolated chimeric antigen receptor (CAR) molecule comprising such an antibody or antibody fragment, a vector comprising a nucleic acid molecule encoding a CAR, as well as a T cell comprising this vector. The present invention is also relative to the use of this T cell (autologous or allogeneic) expressing a CAR molecule to treat a proliferative disease in a mammal.

CAR-T cells targeting IL-1RAP and their use

Diagnostic kit comprising an oligonucleotide probe for the mRNA encoding a polypeptide having an amino acid sequence substantially identical to that of SEQ ID NO: 2.

Truncated CD20 protein, deltaCD20

Isolated nucleic acid sequence encoding the CD20 gene comprising SEQ ID NO: 5, recombinant vector comprising a nucleic acid sequence placed under the control of one or a plurality of elements required for the expression thereof in a host cell, and method for improving the efficacy of a treatment comprising using a nucleic acid sequence comprising SEQ ID NO: 5.

Growing community of inventors

Dampierre, France

Christophe Ferrand