Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Universitaet Hamburg

Universitat Hamburg

Christophe Carola

Herwig Buchholz

Teresa Mujica-Fernaud

Christian Sirrenberg

Wilfried Rautenberg

Tatjana Best

Hansjuergen Driller

Sylvia Huber

Michael Schulte

Michael Krohn

René Peter Scheurich

Lilia Heider

Ralf Rosskopf

Frank Pfluecker

Tatjana Mueller

Sophie Perruchon

Julian Osthoff

Corinna Wirth

Hansjürgen Driller

Hans Neunhoeffer

Ulrich Rabausch

Wolfgang Streit

Rosane Alves Fontes

Evgeniy V Blyumin

Anne Toullec

Henning Rosenfeld

Robin Back

Marina Lefort

The present invention relates to the use of monosubstiuted urea derivatives of the formula I as self-tanning substance, for increasing melanin synthesis, for improving melanin transport and/or improving the distribution of melanin in suprabasal layers, and to preparations comprising these urea derivatives.

Monosubstituted urea derivatives as a self-tanning substance

A use of noreugenin glycoside derivatives of formulas I, II and III as a self-tanning substance or to increase the synthesis of melanin, improve melanin transport and/or improve the distribution of melanin in suprabasal layers, preparations containing noreugenin glycoside derivatives of formulas I, II and III, and noreugenin glycoside derivatives of formulas I, II and III.

Noreugenin glycoside derivatives

The present invention relates to specific &#x3b2;-hydroxyketones of the formula (I) for use in the prevention and/or treatment of photodermatoses and to the use of specific &#x3b2;-hydroxyketones of the formula (I) as active ingredient in typical compositions for the prevention and/or non-therapeutic treatment of photodermatoses, in particular of polymorphic light eruption.

Beta-hydroxyketones as topical active ingredients for the prevention or treatment of photodermatoses

The present invention relates to the use of compounds of the formula (I) for the care, preservation or improvement of the general condition or appearance of the skin or hair, and to preparations comprising compounds of the formula (I).

2-pyrones

The invention relates to the use of specific glucuronolactone derivatives as self-tanning substances, as tanning enhancers for dihydroxyacetone or for a mixture of self-tanning substances comprising dihydroxyacetone, for modulation of the hue achieved in the case of tanning with dihydroxyacetone or by the mixture or preparation comprising dihydroxyacetone, as contrast-reduction agents or for coloring keratin-containing fibers, and to preparations or compositions for coloring keratin-containing fibers comprising these specific glucuronolactone derivatives.

Glucuronolactone derivatives as self-tanning substances

The invention relates to the use of specific glucuronolactone derivatives as self-tanning substances, as tanning enhancers for dihydroxyacetone or for a mixture of self-tanning substances comprising dihydroxyacetone, for modulation of the color shade achieved in the case of tanning with dihydroxyacetone or by the mixture or preparation comprising dihydroxyacetone, as contrast-reduction agents or for coloring keratin-containing fibers, and to preparations or compositions for coloring keratin-containing fibers comprising these specific glucuronolactone derivatives.

The present invention relates to chromen-4-one derivatives of the formula (I), to the use thereof as self-tanning substance or for increasing melanin synthesis, improving melanin transport and/or improving the distribution of melanin in suprabasal layers, and to preparations comprising these chromen-4-one derivatives.

7-acyloxychromen-4-one derivatives and the use thereof as self-tanning substances

The invention relates to the use of chromen-4-one derivatives of the formula I 

Use of chromen-4-one derivatives

The present invention relates to compounds of the formula (I), where Rto Reach, independently of one another, denote H, hydroxyl or alkoxy having 1 to 8 C atoms, Rdenotes alkyl having 1 to 4 C atoms, H, hydroxyl or alkoxy having 1 to 8 C atoms, Rdenotes H or hydroxyl, and Rdenotes H or alkyl having 1 to 18 C atoms, or salts thereof, but where all Rto Rtogether cannot be equal to H, to compositions, and to the preparation and use thereof.

[(4-oxo-4H-chromen-3-yl)hydroxymethyl]- or [(4-oxo-4H-chromen-3-yl)methyl]phosphonic acid derivatives

The invention relates to complexes of certain flavonoid derivatives, of the formula (I), where Rand Rare selected from H and OR, where ORstands, independently of one another, for OH, straight-chain or branched C- to C-alkoxy groups, straight-chain or branched C- to C-alkenyloxy groups, straight-chain or branched C- to C-hydroxyalkoxy groups, where the hydroxyl group(s) may be bonded to a primary or secondary carbon atom in the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or C- to C-cycloalkoxy groups and/or C- to C-cycloalkenyloxy groups, where the rings may in each case also be bridged by &#x2014;(CH)&#x2014; groups, where n=1 to 3, and/or mono- and/or oligoglycosyl radicals, with the proviso that at least one radical from Rand Rstands for OR, and Rto Rmay be identical or different and stand, independently of one another, for radicals which are substantially inert with respect to the UV properties, to compositions which comprise such complexes, to corresponding processes for the preparation of the complexes or the compositions comprising the latter, and to the use thereof, in particular for the care, preservation or improvement of the general condition of the skin or hair and for light protection. 

Flavonoid complexes

The invention relates to novel compositions, in particular cosmetic and/or pharmaceutical compositions or food supplements, comprising at least one oxidized flavonoid derivative of the formula I, to novel oxidized flavonoid derivatives, and to novel uses of the oxidized flavonoid derivatives.

Preparation containing oxidized flavonoid derivatives

The invention relates to compounds of the formula (I) or (II), to compositions which comprise such compounds, to corresponding processes for the preparation of the compounds or the compositions comprising same, and to the use thereof as light-protection filters. 

UV filters

Novel compounds of the formula I in which

2-oxadiazolechromone derivatives

The invention relates to a novel flavonoid derivative, to an extract comprising the flavonoid derivative, to the cosmetic and pharmaceutical use thereof, to preparations comprising the flavonoid derivative or extract, and to a process for the preparation of the flavonoid derivative or extract.

Growing community of inventors

Langen, Germany

Christophe Carola