Sloan-kettering Institute for Cancer Research

Christophe Antczak

David A Scheinberg

Michael R McDevitt

Rena May

Debjit Chattopadhyay

Jon T Njardarson

Mark Reid Phillips

Samuel J Danishefsky

Vadim Y Dudkin

Hakim Djaballah

Mark Reid Philips

Jón T Njardarson

Justin Miller

The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.

Single wall nanotube constructs and uses thereof

The instant invention provides novel benzofuran-4,5-diones and pharmaceutical compositions thereof useful for inhibiting PDF and for treating proliferative and infectious diseases. Compounds may be selective for eukaryotic (e.g., human) PDF or prokaryotic PDF.

Benzofuran-4,5-diones as selective peptide deformylase inhibitors

The present invention provides soluble single wall nanotube constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble single wall carbon nanotube via a DNA or other oligomer platform attached to the single wall carbon nanotube. These soluble single wall carbon nanotube constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble single wall carbon nanotube constructs.

Single wall nanotube constructs and uses therefor

The present invention provides compounds having formula (I): 

Prostate specific antigens and uses thereof

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New York, NY, United States of America

Christophe Antczak