Basf Se Corporation

Evonik Degussa Gmbh

Basf Plant Science Company Gmbh

Helmholtz-zentrum Fuer Infektionsforschung Gmbh

Paik Kwang Industrial Co., Ltd.

Helmholtz-zentrum Fur Infektionsforschung Gmbh

Universität Des Saarlandes

Christoph Wittmann

Oskar Zelder

Stefan Haefner

Judith Becker

Hartwig Schröder

Corinna Klopprogge

Joanna Martyna Krawczyk

Esther Dantas Costa

Gregory Von Abendroth

Elmar Heinzle

René Stellmacher

Stefanie Kind

Burkhard Kröger

Janice G Pero

R Rogers Yocum

Andrea Herold

Thomas A Patterson

Hartwig Schroeder

Hartwig Schroder

Martin Kuhl

Birgit Hoff

Mark K Williams

Mark Broenstrup

Nico Boehmer

Hardy Schön

Thomas J Lyons

Michael Kohlstedt

Regine Fuchs

Mark Brönstrup

Anna Lange

Benjamin J Lyons

Jost Van Duuren

Jens Kroemer

Theron Herman

Anna Christine Schroer

Eudes De Crecy

Patrick Kiefer

Blanka Karge

Ewa Hughes

Olaf Woiwode

Enrico Peter

Detlev Rasch

Veronique Beckers

Lisa Dersch

Joost Van Duuren

Michael Fritz

Nadja Barton

Mirjam Selzer

Michel Fritz

Jozef Van Duuren

Rudolf Richter

Jessica Stolzenberger

Heike Hoeltzen

Sören Starck

Paul De Wild

Bianka Karge

Hartwig SCHRÖDER

Mark Williams

Described herein is a process of producing an organic compound, the process including: I) cultivating a genetically modified microorganism in a culture medium including sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, and II) recovering the organic compound from the fermentation broth obtained in process step I) The genetically modified microorganism includes A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK-gene, compared to the original microorganism that has not been genetically modified, and the original microorganism belongs to the family Pasteurellaceae. Also described herein are a genetically modified microorganism and the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.

Process for producing an organic compound

A method for determination of the growth rate of biofilm using an electrical impedance analyses is disclosed. The method comprises the steps of: bringing a culture medium fluid in contact to an electrode structure, having biofilm grown within the fluid culture medium with the biofilm arranged in distance to the electrodes structure, so that the fluid culture medium is placed between the growing biofilm and the electrode structure; measuring the impedance of the electrodes structure over a monitoring time, and determining the growth rate of the biofilm as a function of the reduction rate of the impedance values measured on the electrode structure.

Method and measuring device for determination of the growth rate of biofilm

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.

Microorganisms for succinic acid production

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.

Modified microorganism with improved biomass separation behaviour

Recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine or N-acetylcadaverine, as well as recombinant DNA molecules and polypeptides used to produce the microorganisms are provided. Said microorganisms comprise an intracellular lysine decarboxylase activity and a deregulated cadaverine export activity, or comprise a decreased cadaverine export activity and an enhanced N-acetylcadaverine forming activity. Processes for the production of cadaverine N-acetylcadaverine using the recombinant microorganisms are also provided.

Processes and recombinant microorganisms for the production of cadaverine

The present invention relates to an isotope labeling chamber for labeling metabolites in an organism, comprising a reactor chamber () and an air regulation chamber (), wherein the reactor chamber () comprises the following components: optionally, a housing frame (), housing walls (), at least one injection valve (), where at least one housing wall () can be opened fully and/or in part and where at least one housing wall has a lock (), and furthermore wherein the air regulation chamber () comprises the following components: a temperature-regulating unit (), an air humidification unit () and a gas absorption unit (). Furthermore, the invention relates to a labeling method for plants in which the labeling chamber according to the invention is employed.

Method and device for marking isotopes

Recombinant microorganisms with deregulated succinyl-CoA synthetase activity, as well as the uses for producing lysine, &#x3b2;-lysine, cadaverine or N-acetylcadaverine thereby are provided. Recombinant polypeptides comprising an amino acid sequence being at least 80% identical to SEQ ID NO: 51 or 53 are also provided. The method of producing fine chemicals using said recombinant microorganisms, in particular the method of producing lysine, or derivatives thereof, such as &#x3b2;-lysine, cadaverine or N-acetylcadaverine is further provided.

Processes and recombinant microorganisms for the production of fine chemicals

The present invention is directed to a method utilizing a recombinant microorganism for the production of aspartate derived amino acids and precursors thereof, in particular for the production of L-lysine. Furthermore, the present invention relates to a recombinant microorganism having improved aspartate-derived amino acid synthesis activity in comparison to the initial microorganism and the use of such microorganisms in producing said amino acids and precursors and derivatives, in particular in the synthesis of L-lysine.

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The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.

Microorganism and process for the preparation of L-methionine

The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g.,by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine inby way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

Growing community of inventors

Saarbrücken, Germany

Christoph Wittmann