University of Leeds

Cambridge University Technical Services Limited

Cambridge Enterprise Limited

Christoph Walti

Alexander Giles Davies

Rene Wirtz

Anton Peter Jacob Middelberg

Paul Ko Ferrigno

Michael Pepper

Christopher David Wood

Steven Johnson

Alban Josiah Smith

Richard O'Rorke

David Evans

A method and apparatus for manipulating polarizable dielectric particles. The method includes positioning a liquid containing the particles above a surface of a piezoelectric material (). The method also includes inducing a shear-horizontal surface acoustic wave in the piezoelectric material (), thereby to form a time-varying non-uniform evanescent electric field extending into the liquid. The method further includes using the time-varying non-uniform evanescent electric field to apply a force to at least some of the particles () by dielectrophoresis.

Method and apparatus for manipulating particles

The disclosure relates to a method of detecting a structural change in a molecule that is attached to a surface that is electrically conductive, wherein the method includes monitoring the phase of the electrochemical impedance at the surface, and wherein a change in the phase indicates a change in the structure of the molecule. The disclosure also relates to arrays and methods for making arrays having molecules, such as polypeptides, attached to electrically conductive surfaces, such as electrodes.

Methods and devices for detecting structural changes in a molecule measuring electrochemical impedance

The present invention provides a method of forming coatings of at least two different coating molecules on at least two electrodes, the method comprising: (a) providing an array of at least two individually-addressable electrodes, (b) allowing a layer of a masking molecule to adsorb onto all electrodes, (c) inducing electrochemical desorption of the masking molecule from at least one but not all electrodes to expose a first set of exposed electrodes, (d) allowing a first coating molecule to adsorb onto the first set of exposed electrodes, (e) exposing all electrodes to a masking molecule to allow adsorption of the masking molecule onto all electrodes, (f) inducing electrochemical desorption of masking molecule from a second set of electrodes to expose a second set of exposed electrodes, (g) allowing a second coating molecule to adsorb onto the second set of exposed electrodes.

Arrays of electrodes coated with molecules and their production

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Leeds, United Kingdom

Christoph Walti