Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Rheinisch-Westfaelische Technische Hochschule Aachen

Rheinisch-Westfalische Technische Hochschule Aachen

Christoph Stein

Rainer Fischer

Stefan Barth

Radoslav Mladenov

Bernhard Stockmeyer

Lea Christin Schenke

Complexes suitable for targeting and killing a human target cell comprising a first polypeptide with a binding structure for binding the complex to the cellular surface receptor CD89 (e.g. with an anti CD89 antibody) presented on the cell surface of the human target cell and a second polypeptide comprising a toxic effector domain, preferablyexotoxin A); to nucleic acid molecules encoding said complexes, vectors, host cells containing the nucleic acids and methods for preparation and producing such complexes; compositions and methods for using said complexes for the treatment of diseases, in particular of cancer diseases like leukemia.

Anti-CD89 cytotoxic complex

Growing community of inventors

Darmstadt, Germany

Christoph Stein