Charité – Universitätsmedizin Berlin

Dendropharm Gmbh

Konrad-zuse-institut

Stein, Christoph

Christoph Stein

Rainer Haag

Sam Moré

Florian Paulus

Olga Scharkoi

Halina Machelska-Stein

Christian Zöllner

Michael Unbehauen

Emanuel Fleige

Marcus Weber

Peter Deuflhard

Halina Machelska

Olga Perepelica

The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.

Analgesic preparation with nanocarriers and use thereof

The invention relates to fluorinated fentanyl derivatives that function as opioid receptor agonists, which activate target opioid receptors in a pH-dependent manner, and are thus selective for the receptors in inflamed (acidic) milieu; uses thereof and pharmaceutical compositions comprising them.

Fentanyl derivatives as pH-dependent opioid receptor agonists

Growing community of inventors

Berlin, Germany

Christoph Stein