Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

Boehringer Mannheim Gmbh

Roche Molecular Systems, Inc.

Hoffmann-La Roche Inc.

Roche Sequencing Solutions, Inc.

Dako A/s

F. Hoffmann-La Roche Ag

Christoph Seidel

Ursula-Henrike Wienhues

Dieter Heindl

Frank Bergmann

Hans-Peter Josel

Uwe Kobold

Michael Wiedmann

Martin Rempt

Herbert Von Der Eltz

Urban Schmitt

Barbara Upmeier

Andreas Gallusser

Elke Faatz

Luisa De Cola

Manfred Motz

Erwin Soutschek

Michael Grol

Volker Klemt

Klaus Hallermayer

Anneliese Borgya

Sebastian Dziadek

Robert Cysewski

Jesus Miguel Fernandez Hernandez

Giuseppe Prencipe

Simon Ferdinand Loibl

Eva Höss

Jelena Milic

Eva Hoess

Andreas Leinenbach

Kurt Weindel

Hannes Kuchelmeister

Hubert Bayer

Silvia Baecher

Eva H&ouml;ss

Hans Georg Ihlenfeldt

Geoffrey Burns

Anna-Skrollan Geiermann

Nicole Pirkl

Rupert Herrmann

Dmitriy Gremyachinskiy

Frank Seela

Thomas Meier

Rainer Schmuck

Wilhelm Tischer

Andrew Trans

Angelika Roesler

Klaus Reichert

Beatus Ofenloch-Hahnle

Dirk Kessler

Bernd Schneidinger

Wilma Thuer

Wolf-Dieter Engel

Friedrich Popp

Lars Hillringhaus

Georg Becher

Gabriele Pestlin

G&uuml;nther Gerhard Jung

Ursula Henrike Wienhues

Gertraud Ehrlich-Weinreich

Gerhard Lassonczyk

Robert Hahn

Hans-Georg Batz

Johann Karl

Michael Schraeml

Helmut Lenz

Troels Koch

Ursula Klause

Elena Longhi

Guenther-Gerhard Jung

Beatus Ofenloch-H&auml;hnle

Peter Bialk

Thomas Hoffmann

Jens Christian Bolle

Sandra Recklies

Cornelia Kruse-Müller

Beatus Ofenloch-Hähnle

Cornelia Kruse-M&uuml;ller

Wolf-Deiter Engel

Daniela Mazzier

Thomas Heinemeyer

The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

Reagent for mass spectrometry

The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

Benzylpyridinium reagent for mass spectrometry

A method for identifying a reagent during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a reagent, adding at least one chemical substance to the reagent with a concentration being below a detection level of the mass spectrometer, enriching the chemical substance within the liquid chromatograph to a concentration above the detection level of the mass spectrometer, processing the reagent together with the enriched chemical substance by means of the analysis system, and identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance.

Method for identifying a reagent during a process in an analysis system

A method for identifying a reagent during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a reagent, adding at least one chemical substance to the reagent with a concentration being above a detection level of the mass spectrometer, processing the reagent together with the chemical substance with the analysis system, and identifying the reagent based on a detection of a substance detection signal of the mass spectrometer representing the chemical substance.

The present disclosure relates to compositions and methods based on polypeptide-tagged nucleotide, and the use of such polypeptide-tagged nucleotides in nanopore devices and methods.

Polypeptide tagged nucleotides and use thereof in nucleic acid sequencing by nanopore detection

A binding agent of the Formula A-a':a-S-b:b&#x2032;-B:X(n), wherein A as well as B is a monovalent binder, a&#x2032;:a as well as b:b&#x2032; is a binding pair wherein a&#x2032; and a do not interfere with the binding of b to b&#x2032; and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a&#x2032;, a, b, b&#x2032; or S, (n) is an integer and at least 1, &#x2014; represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

Binding agent

Disclosed is a simplified process for producing magnetic polymer particles. The process comprises: (a) providing a composition having a liquid monomer which is radical polymerizable, a radical initiator soluble in the monomer, a steric stabilizer, and a ferrofluid comprising surfactant-coated colloidal magnetic particles in a carrier fluid which is miscible with the monomer; (b) preparing an emulsion from a polar solvent which is immiscible with the monomer, and the composition of step (a); (c) adding seed polymer particles to the emulsion, mixing to form a seeded emulsion, and incubating the seeded emulsion, thereby swelling the seed polymer particles; and (d) activating the radical initiator and polymerizing the monomer in the swollen seed polymer particles; thereby producing the magnetic polymer particles. The process forms monodisperse magnetic particles. The particles are characterized by a uniform distribution of magnetic material, and an absence of magnetite bleeding.

Process for producing magnetic monodisperse polymer particles

The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.

Iridium-based complexes for ECL

The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner. 

Directed synthesis of oligophosphoramidate stereoisomers

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Weilheim, Germany

Christoph Seidel