Cardioklne, Inc

Christoph Schmidt

Andrew Xian Chen

Hailiang Chen

Khawla Abu-Izza

Patricia Frech

Compositions and methods of making the same for in vivo delivery of lixivaptan to a subject in need thereof are described. The composition includes a substantially water-insoluble pharmacologically active agent (e.g., lixivaptan) and a substantially water-insoluble matrix forming material (e.g., a Vitamin E semi-ester), wherein the pharmacologically active agent is dispersed in said matrix forming material, and wherein the composition delivers said substantially water-insoluble pharmacologically active agent upon exposure to physiological medium.

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Lausanne, Switzerland

Christoph Schmidt