Glycom A/s

Christoph Röhrig

Lars Kröger

Gyula Dekany

Markus Jondelius Hederos

Ioannis Vrasidas

Piroska Kovács-Pénzes

Károly Ágoston

István Bajza

Ferenc Horváth

Gergely Pipa

Ignacio Pérez Figueroa

Johan Olsson

Gyula Dékany

Elise Champion

Martin Matwiejuk

Markus Hederos

Andreas Schroven

Julien Boutet

Christian Risinger

Ágnes Ágoston

Marie Bøjstrup

Sándor Demkó

Péter Trinka

Istvan Bajza

László Kalmár

Ignacio Figueroa Pérez

Ignacio Figuero-Pérez

Ignacio Fegueroa Pérez

Erzsébet Czinege

Paulo Vital

Ignacio Figueroa-Pérez

Gábor Kádár

Sándor Demkò

Krisztián Kovàcs

Ferenc Horvàth

Ágnes Jànosi

Irme Kovács

Ågnes Jánosi

Mette Fanefjord

Imre Kovács

Gyula DÉKANY

The present invention relates to a method for preparation of the trisaccharide 6'-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6&#x2032;-O-sialyllactose salts in pharmaceutical or nutritional compositions. 

Production of 6'-O-sialyllactose and intermediates

A compound of the formula (1) wherein Ris a group removable by hydrogenolysis, and wherein Ris OH or Ris &#x2014;NHRwherein Ris a group removable by hydrogenolysis. The compound can be made from fructose by a Heyns-rearrangement. The compound can be used then to make free D-mannosamine or its salts, D-mannosamine building blocks and mannosamine containing oligo- or polysaccharides, N-acetyl-D-mannosamine and its hydrates and solvates, neuraminic acid derivatives, and viral neuraminidase inhibitors.

N-substituted mannosamine derivatives, process for their preparation and their use

The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an &#x3b1;-sialyl moiety and the other is H, Xrepresents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, Ris a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.

Synthesis of sialooligosaccharide derivatives

The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates. 

Method for the synthesis of a trisaccharide

The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions. 

Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine

The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates. 

The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.

Method for crystallization of fucose

The present invention relates to novel polymorphs of the trisaccharide 2'-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions. 

Polymorphs of 2'-O-fucosyllactose and producing thereof

A 1,2-dideoxy-1,2-diamino oligosaccharide or polysaccharide in its free base, salt or metal-complex form as shown in General Formula 1 and derivative thereof is described. R, Rand Rare each independently selected from the group consisting of H and a carbohydrate moiety, with the proviso that at least one of the groups R, Ror Ris a carbohydrate moiety; Ris selected from the group consisting of: H, optionally substituted C-alkyl, optionally substituted heteroalkyl, optionally substituted C-alkenyl, optionally substituted C-alkynyl, optionally substituted C-cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl.

1,2-dideoxy-1,2-diamino oligosaccharides and polysaccharides and derivatives thereof

&#x3b1;-Lactosamine hydrochloride, substantially free of &#x3b2;-lactosamine hydrochloride; a method of preparing &#x3b1;-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lactosamine hydrochloride, water and at least one water-miscible organic solvent at a temperature of 0-100&#xb0; C., and cooling the solution to cause crystallization of &#x3b1;-lactosamine hydrochloride monohydrate; a method of preparing anhydrous &#x3b1;-lactosamine hydrochloride; and use of &#x3b1;-lactosamine hydrochloride as a food supplement or intermediate in synthesis.

Crystalline carbohydrate derivative

Growing community of inventors

Mühlingen, Germany

Christoph Röhrig