Novartis Vaccines & Diagnostics, Gmbh

Chiron Corporation

Nuvelo, Inc.

Christoph Reinhard

Anne B Jefferson

Joerg Kaufmann

Vivien W Chan

Giulia C Kennedy

Ronald N Zuckermann

Michael A Innis

Jaime A Escobedo

Filippo M Randazzo

David Pot

Pablo Dominguez Garcia

Altaf Kassam

Greg Harrowe

George Lamson

Julie Sudduth-Klinger

Lewis T Williams

Rhonda Hansen

Sanmao Kang

Radoje Drmanac

Snezana Drmanac

Klaus Giese

David B Kita

Ivan Labat

Birgit Stache-Crain

Jill Winter

Lee William Jones

Veronica Garcia

Dena Leshkowitz

Mark Dickson

Radomir Crkvenjakov

Edward J Moler

Eric Beausoleil

Timothy S Burkoth

Venkatakrishna Shyamala

Hong Xin

Deborah Lee Zimmerman

Shuling Fang

Tasha Marenbach

Douglas R Den-Otter

Hamiduddin Khoja

Anne Bennet Jefferson

Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.

Cell transfecting formulations of small interfering RNA related compositions and methods of making and use

A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.

Genes differentially expressed in breast cancer

The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.

Gene products differentially expressed in cancerous cells

The invention provides, inter alia, models of bone metastasis, methods for identifying agents that modulate skeletal related events and metastasis, methods for modulating skeletal related events and metastases, and methods for detecting skeletal related events and metastases. The methods and models generally comprise co-culturing cancer cells and host cells and comparing biological markers from such co-cultured cells to control cells.

Methods of modulating metastasis and skeletal related events resulting from metastases

HX2004-6 polypeptide expressed in cancerous cells

A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided.

Human cyclin-dependent kinase (hPNQALRE)

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The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.

Detection of colon or breast cancer by measuring TTK polynucleotide expression

Detection of colon or breast cancer by measuring TTK polypeptide expression

Determining prognosis of colon or breast cancer by measuring TTK expression

Different-sequence peptoids, including lipid- and sterol-conjugated peptoids, are found to be effective in transfection of cells with oligonucleotides. Combinatorial libraries of such peptoids can be screened efficiently in a high-throughput format, and selected peptoids are identified post-screening.

Oligonucleotide transfection screening method

This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

Human genes and gene expression products V

Growing community of inventors

Alameda, CA, United States of America

Christoph Reinhard