Perkinelmer Cellular Technologies Germany Gmbh

Evotec Technologies Gmbh

Christoph Reichle

Thomas Schnelle

Torsten Müller

G&uuml;nter Fuhr

Torsten M&uuml;ller

Gabriele Gradl

Henning Glasser

A method is described for non-destructive measurement of vitality of biological cells, especially for determination of apoptosis, in which the at least one cell is exposed to high-frequency alternating, especially rotating, electric fields and/or impedance test fields, and at least one rotation measurement, one dielectrophoresis measurement and/or one impedance measurement is performed with the cell for at least one frequency range or individual frequencies, from which at least one measurement parameter is determined that is characteristic of the vitality state of the cell.

Method for measuring the vitality of cells

For object detection, particularly in fluidic microsystems, optical imaging of at least one resting or moving object ( ) on a structured mask ( ) with at least one segment from a flat section ( ), in which the object ( ) is located at least partially or temporarily and which has a characteristic dimension smaller than the dimension of the object ( ) or its movement path, to a detector unit, detection of the quantity of light transmitted by the structured mask ( ), and generation of a detector signal which has a predetermined relationship with the quantity of light, and evaluation of the detector signal in regard to the presence of the object ( ), its position, its shape and/or the temporal change of the position are performed.

Process and device for the detection of microscopically small objects

Growing community of inventors

Berlin, Germany

Christoph Reichle