Merck Patent Gmbh

Christoph Mürmann

Andreas Bathe

Joachim Kralik

Kai Fabian

Heinz Hermann Bokel

Ralf Knieriemen

Thomas Keil

Norbert Schweickert

Heinz Bokel

A process for the enantioselective preparation of amino alcohols of formula I by enantioselective hydrogenation of amino ketones of the formula II in the presence of a non-racemic catalyst. The catalyst is a transition-metal complex in which the transition metal is complexed to a chiral diphosphine ligand.

Process for the enantioselective hydrogenation of amino alcohols

The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands.

Method for producing 5-aryl nicotinaldehydes

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Reinheim, Germany

Christoph Mürmann