Boehringer Ingelheim International Gmbh

Other

Boehringer Ingelheim Pharma Gmbh & Co Kg

Christoph Kreher

Hubert Hoelz

Christian Scheffler

Dieter Hochrainer

Georg Boeck

Michael Spallek

Herbert Wachtel

Burkhard Metzger

Michael Walz

Michael Trunk

Jochen Ziegler

Daniela Bothe

Stephanie Ossadnik

In a method for checking the permeability rate of a closed container () with respect to a medium, in particular for checking the permeability rate of a film-type container for accommodating a film container for accommodating a pharmaceutical active constituent formulation, the container () is filled with a medium, charged with a gas, and the increase in the amount of medium in the gas is then analysed.

Method for checking the permeability rate of a closed container

The measurement of the particle size distribution of an aerosol is of crucial importance in pharmaceutical development. A prerequisite for this is a valid method, e.g. the cascade impactor method described in the pharmacopoeias. It requires measurement of the active substance concentration in order to determine the particle size distribution. The invention provides a process which makes it possible to measure the size of aerosol droplets containing pharmaceutical substances which are unstable in the event of changes in the pH.

Process for determining the particle size distribution of an aerosol and apparatus for carrying out such a process

Disclosed herein are methods for measuring the particle size distribution of a pharmaceutical aerosol, including methods utilizing laser diffraction.

Measuring particle size distribution in pharmaceutical aerosols

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Ingelheim, Germany

Christoph Kreher