Credentis Ag

Naviswiss Ag

Christoph Hämmerle

Bruno Knobel

Michael Hug

Dominikus Amadeus Lysek

Charles Findeisen

Erwin Keeve

Frank Bartl

Franziska Koch

Nina Meyer

Stephanie Mathes

Frank Bröseler

Uwe Pieles

Karl-Heinz Widmer

The present invention provides a composition comprising specific self-assembling peptides, which are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-12, PI 1-16, PI 1-18, PI 1-26 or PI 1-31 for use in treating an oral disease selected from the group consisting of gingivitis, periodontitis and/or peri-implantitis in a subject. Said composition may be used, after suitable cleaning procedures, for filling pockets formed adjacent to teeth in said diseases, which enhances tissue regeneration. The composition may be suitable for controlled release of an active agent, e.g., an antimicrobial or antibiotic agent. The invention also provides a kit suitable for said treatment further comprising self-assembling peptides suitable for forming a second layer on top of the first composition.

Composition comprising self-assembling peptides for use in treatment of gingivitis, periodontitis and/or peri-implantitis

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Benglen, Switzerland

Christoph Hämmerle