Harvard College

Other

Louisiana State University and Agricultural & Mechanical College

Cliff-cartwright Corporation

Christoph H Westphal

Philip Leder

Iris Lindberg

Thomas Wessel

Described herein are compositions comprising activators of TRP and ASIC channels that may be useful to improve or preserve exercise performance and exercise recovery.

Compositions and methods affecting exercise performance

In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous recombination. The invention also features transgenic non-human mammals, and eukaryotic cells, wherein a gene encoding 7B2 protein is modified, as well as nucleic acid vectors capable of undergoing homologous recombination with an endogenous 7B2 gene in a cell. The invention also features transgenic non-human mammals as models of endocrine disorders, as well as methods for diagnosing and treating patients with endocrine disorders.

7B2 knockout transgenic animals as models of endocrine disease

Methods and uses for transposon-based gene targeting

Growing community of inventors

Waltham, MA, United States of America

Christoph H Westphal