Beckman Coulter, Inc.

Advalytix Ag

Christoph Gauer

Wolfgang Mann

Achim Wixforth

Zeno Von Guttenberg

A method for concentrating materials in a liquid involves pouring the liquid into a material-containing receptacle and irradiating the liquid by acoustic waves so that a stationary flow pattern with different flow rate areas is formed in the receptacle. A concentration device and reaction method using such concentration are also provided.

Acoustic concentration method and device and a reaction method

The invention relates to a mixing method for mixing at least one small quantity of liquid, in which a quantity of liquid is applied in a reaction region and at least one surface sound wave is reacted with the quantity of liquid. The invention relates further to a mixing device for mixing at least one quantity of liquid for performing the method of the present invention, a use of the device, and a method of analysis for bond strengths on surfaces.

Mixing device and mixing method for mixing small amounts of liquid

A method or device for integrated dosing and intermixing of small amounts of liquid, has a first liquid conveyed into or onto a first reservoir (). A second reservoir () is entirely filled with a second liquid. The first and second liquids are brought into contact with each other via at least one joining duct structure () which has at least one area provided with a smaller cross section than the reservoirs () in the viewing direction of the connecting line between the two reservoirs (). A laminar flow pattern is created along at least one portion of the joining duct structure (), with the liquids thoroughly mixed in the second reservoir ().

Method and device for dosing and mixing small amounts of liquid

A method or device for integrated dosing and intermixing of small amounts of liquid, has at least one dosing reservoir () connected to a reaction reservoir () via at least one joining structure () and entirely filled with a first liquid. The at least one joining structure () is preferably dimensioned such that surface tension of the first liquid prevents the first liquid from penetrating into the reaction reservoir () which is entirely filled with a second liquid contacting the first liquid on the joining structure (). A flow pattern is created in or on the reaction reservoir () to thoroughly mix the two liquids.

The invention relates to a method for the analysis of macromolecules using a microarray on which a plurality of first at least partly different macromolecules are located in a known arrangement, wherein the microarray is arranged on a solid surface on which a region is defined whose wetting properties differ from the surrounding solid surface such that a liquid with a plurality of second macromolecules preferably stays thereon, the liquid with the second macromolecules is brought onto the solid surface and at least partly removed and the second macromolecules remaining after the removal process are detected in order to determine from the position which of the first macromolecules have formed a bond with second macromolecules. The invention further relates to a method wherein a surface wave is launched to the liquid to distribute and/or thoroughly mix the liquid on the microarray.

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Munich, Germany

Christoph Gauer