Actelion Pharmaceuticals Ltd

Christoph Binkert

Oliver Nayler

Claus Mueller

Boris Mathys

Michael Scherz

Martin Bolli

Thomas Weller

Martine Clozel

Hamed Aissaoui

Christoph Boss

Olivier Corminboeuf

Corinna Grisostomi

Jörg Velker

Solange Meyer

J&ouml;rg Velker

Nayler Oliver

The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

Thiazolidin-4-one-derivatives

Thiazolidin-4-one derivatives

Thiazolidin 4-one derivatives

The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, especially malaria.

Piperazines as antimalarial agents

The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4- one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.

Quinoline derivatives

The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists especially urotensin II antagonists.

1,2,3,4-Tetrahydroisoquinolines derivatives as urotensin II receptor antagonists

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Basel, Switzerland

Christoph Binkert