Gsi Helmholtzzentrum Fur Schwerionenforschung Gmbh

Siemens Aktiengesellschaft

Gsi Helmholtzzentrum Fuer Schwerionenforschung Gmbh

Forschungszentrum Dresden-rossendorf E.v.

Gesellschaft Für Schwerionenforschung Mbh

Heidelberger Ionenstrahl-therapie (hit) Betriebs-gesellschaft Am Universitatsklinikum

Gsi Helmfoltzzentrum Fur Schwerinonenforschung Gmbh

Gsi Helmholtzzentrum Fur Schwerionenforschuntg Gmbh

Heidelberger Ionenstrahltherapie (hit) Betriebs-gesellschaft Am Universitätsklinikum Heidelberg Mbh

Helmholtz-zentrum Dresden-rossendorf E.v.

Heidelberg Ionenstrahl-therapie (hit) Betriebs-gesellschaft Am Universitätsklinikum Heidelberg Mbh

Christoph Bert

Eike Rietzel

Alexander Gemmel

Gerhard Kraft

Nami Saito

Robert Luechtenborg

Daniel Richter

Thomas Haberer

Dieter Schardt

Wolfgang Enghardt

Bernhard Franczak

Christoph Schuy

Peter Steidl

Christian Graeff

Katia Parodi

Dirk Müssig

Martin Rohregger

Elke Rietzel

Chaudhri Naved

Pleskac Radek

Robert Lüchtenborg

Elko Schubert

Robert LÜCHTENBORG

Johnny Nguyen

Alexander Schmidt

Radek Pleskac

Naved Chaudhri

A method is disclosed for irradiation planning for the irradiation of a moving target volume located in a body with a particle beam irradiation facility by means of rescanning, which method has the steps of defining the target volume in a reference condition of the motion, dividing the target volume among a plurality of target points that can be individually approached with a particle beam, calculating a nominal dose to be deposited in each of the target points of the target volume, defining a number of rescanning passes in which each of the target points of the target volume are approached, calculating a mean motion to be expected of the target points of the target volume based on a motion model, taking into account the mean motion to be expected of the target points of the target volume in the irradiation planning in such a manner that the deviation of the expected dose deposition from the nominal dose for each target point is determined, and the nominal dose for each target point is corrected on the basis of the deviation, and generation of control parameters for the irradiation facility, wherein the control parameters comprise a particle count per target point and rescanning pass to be applied.

Planning the irradiation of a particle beam while taking into consideration a movement of a target volume

Method for irradiation planning of a target volume with a scanned particle beam, comprising the following steps: defining a target volume located in a body, subdividing the target volume into a plurality of individually approachable target points, defining a number of temporally consecutive irradiation sub-plans, dividing the target points of the target volume among the irradiation sub-plans in subsets, wherein the subsets are distributed over the entire target volume, and wherein mutually adjacent target points of the target volume are each assigned to different irradiation sub-plans.

Method for irradiation planning

A method for determining a dose of radiation input into an object irradiated with an energetic particle beam includes determining, during the application of the radiation, a dose input into at least one volume region of the object. The at least one volume region of the object lies outside a target volume region. The dose input into the at least one volume region is determined with a calculation that is based at least in part on a physical model of the energetic particle beam.

Method for determining a dose entering an object that is to be irradiated

A method for preparing a radiation treatment plan for irradiating a target volume region moving in regions in an object with a moving particle beam includes determining, using a mapping function dependent on a movement state (k) of the moving target volume region, a dose input in at least one target point volume (Vj). The dose input is brought about by applying the particle beam to an irradiation point (Bi).

Method for preparing an irradiation plan for a moving target volume without a movement compensation

The idea concerns irradiation of a target volume (), wherein intensities for target points () are determined which are sequentially approached by a beam, comprising the following steps: detecting a volume () to be protected, wherein a dose generated by irradiating a target volume () does not exceed a predetermined maximum value; determining intensities for target points () in such a way that within the volume () to be protected the generated dose does not exceed the predetermined maximum value, wherein a dose contribution data record is used for determining the intensities, which dose contribution data record comprises the dose generated at other spots () by directing the beam () on one of the target points () with a predetermined intensity.

Irradiation of a target volume, taking into account a volume to be protected

The present disclosure relates to a method and to an irradiation system for irradiating a moving target volume with an ion beam, in particular for tumor therapy, wherein ion radiography measurements of the target volume are performed and the irradiation for deposition purposes and for radiography purposes is performed with the same ion beam but consecutively in time by alternating the energy of the ion beam between a higher radiography energy and a lower deposition energy using, for example, a passive energy modulator proximal with respect to the patient.

Method and irradiation installation for irradiating a target volume

To control of an irradiation installation, a particle beam is generated with a beam intensity, and a beam quality of the particle beam is monitored with a beam monitoring device. One of several adjustable measurement ranges is selected, wherein the measurement range of the beam monitoring device is set depending on the beam intensity of the particle beam and/or depending on a particle count to be applied.

Irradiation installation and control method for controlling same

The present disclosure relates to a particle energy modulating device for variably changing the energy of the particles of a particle beam. The particle energy modulating device has a variable energy varying device with a control value correcting device for correcting a supplied control value. The control value correcting device corrects the supplied control values through the use of previously determined calibration data.

Energy modulator

A method for controlling dosage application during irradiation of a moveable target volume in a body with an energy beam by scanning the target volume includes, before irradiating an i-th grid position, determining a dosage during the irradiation process using the movement data, wherein the dosage already contains the i-th grid position during irradiation of the previous grid positions (1&#x3c;=k&#x3c;i). Depending on the determined dosage that already contains the i-th grid position during the irradiation of the previous grid positions (1&#x3c;=k&#x3c;i), a compensation value for the i-th grid position is calculated, and depending on the compensation value and on the nominal particle fluence for the i-th grid position, a compensated particle fluence (F) is calculated for the i-th grid position in order to irradiate the i-th grid position with the compensated particle fluence (F).

Method and device for controlling dosage application during irradiation

The invention concerns a process for the deposition of an intended dose distribution in a cyclically moved target region moving cyclically () by means of multiple irradiations with a beam () approaching matrix points of a target matrix in at least two scannings, wherein in each of the scannings, matrix points are approached sequentially. It is characterized through the steps: establishing the maximal tolerance level for local deviation from the intended dose distribution, de-synchronizing the sequence of the irradiation and the cyclical motion of the target region (), and partitioning the irradiation of the target region () in a sufficient number of scannings such that local deviations from the intended dose distribution correspond at most to the maximal tolerance level of deviation from the intended dose distribution. Furthermore, the invention also concerns an irradiation apparatus for executing a process of this type and a process for determining the control parameters for said irradiation apparatus.

Deposition of an intended dose distribution in a cyclically moved target area

A method actuates a device for irradiating an object that has at least one target volume to be irradiated and at least one volume to be protected. The method includes defining at least one signal dose value for the volume to be protected and irradiating the object at least one of at least at times and at least in part with hadron irradiation. A dose introduced into the volume to be protected during the irradiation of the object is determined and at least one signal is emitted as soon as the introduced dose exceeds at least one signal dose value in at least one point of the volume to be protected.

Irradiation method and device for carrying out the method

The invention relates to a method for checking an irradiation installation in which a dose distribution is deposited in a target object by means of a treatment beam, said method comprising the following steps: an irradiation planning data record optimized for the irradiation of a moving target volume is provided; a movement signal that reproduces a movement of the target volume is provided; a phantom is irradiated, said phantom being formed for detecting a dose distribution deposited in the phantom during or after the irradiation, using the control parameters stored at the irradiation planning data record and the movement signal; a dose distribution deposited in the phantom is determined; a dose distribution to be expected is calculated on the basis of parameters that are related to the control of the irradiation installation during the irradiation; and the determined dose distribution deposited in the phantom is compared to the calculated dose distribution to be expected. The invention also relates to a corresponding device and an irridation installation comprising such a device.

Method and device for checking an irradiation planning system, and irradiation system

The invention concerns a device and a process for adjusting the range of an ion beam, in particular for irradiation in tumor therapy. For this purpose, first the reference position of a target volume to be irradiated is determined. Subsequently, the range of an ion beam is configured such that said beam is adjusted to the reference position of the target volume, in such a manner that the Bragg peak, i.e. the maximal energy loss and thereby the maximal damage occurs in the region of the target volume which is to be destroyed. In the case that it has been determined that the reference position has been altered by a movement of the target volume, the ion beam is then deflected from the beam axis such that the ion beam is directed to various regions of a range modulator, in order that the ion beam experience a correspondingly adjusted energy loss in passing through the range modulator. This energy loss is adjusted to correspond to the change in position of the target volume in such a manner that the change in position is compensated for by the adjustment of the range of the ion beam, and the Bragg peak is returned to the region within the target volume.

Quick regulation of the range of high-energy ion beams for precision irradiation of moving target volumes

A radiation phantom device includes at least one movement device for moving at least one first sub-region of the radiation phantom device. The radiation phantom device has, at least one of at times or in regions, radiation properties which are in conformity with a radiation phantom model.

Radiation phantom

A phantom device for in-vitro validation of radiation procedures under motion influence in consideration of an effective biological dose includes a phantom having a first biological detector with a first biological sample. The first biological sample includes a plurality of culturing and irradiation elements. Each of the culturing and irradiation elements are provided with a respective biological sub-sample so that the first biological detector is configured as a spatially resolving biological detector. A first motion device is configured to move the first biological detector so as to simulate a motion of a target volume.

Phantom for the experimental in-vitro validation of radiation procedures under the influence of motion, taking into account the biological effective dose

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Aschaffenburg, Germany

Christoph Bert