Biopolymers, Inc.

Collaborative Research, Inc.

Christine V Benedict

Paul T Picciano

Nishith Chaturvedi

A cell culturing system, methods for the preparation thereof, and methods for affixing other biologically active moieties to a substrate are provided. Said cell culturing system comprises: a substrate; a coating thereon of a sterile formulation comprising polyphenolic protein containing from about 35 to 100% by weight pure bioadhesive polyphenolic protein having the repeating decapeptide unit: ##STR1## wherein N is a whole number ranging from about 10 to about 100, wherein each X is independently selected from the group consisting of hydroxyl and hydrogen, and wherein each R is independently selected from the group consisting of hydrogen and methyl; viable cells affixed to said coated substrate; and a nutritive medium contacting said cells, whereby said cells perform normal metabolic cell functions.

Bioadhesives for cell and tissue adhesion

An adhesive or coating formulation useful in biomedical application and particularly well suited for use in aqueous environments is provided comprising:

Adhesives derived from bioadhesive polyphenolic proteins

A water soluble cationic peptide-containing graft copolymer exhibiting a number average molecular weight of from about 30,000 to about 500,000 are provided comprising:

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Farmington, CT, United States of America

Christine V Benedict