Tapestry Pharmaceuticals, Inc.

Christine R Xu

James D McChesney

Teruna J Siahaan

Madhavi C Chander

Sterling K Ainsworth

A molecular conjugate is provided having the formula: wherein Ris a de-hydroxyl or de-amino moiety respectively of a hydroxyl-bearing or amino-bearing biologically active molecule or an analog or derivative thereof, and Z is &#x2014;O&#x2014; or &#x2014;NH&#x2014;, respectively, Y is a straight or branched alkyl having 1 to 20 carbons that may be optionally substituted with one or more phenyl, a cycloalkyl optionally substituted with one or more alkyl or phenyl, or an aromatic group optionally substituted with one or more alkyl groups, electron-withdrawing groups, or electron-donating groups; and Ris &#x2014;CH&#x2550;CH(W), &#x2014;CH(OH)CH(OH)W, or &#x2014;C(O)H, where W can be H, a straight or branched alkyl having 1 to 20 carbons that may be optionally substituted with one or more phenyl, a cycloalkyl optionally substituted with one or more alkyl or phenyl, or an aromatic group optionally substituted with one or more alkyl groups, electron-withdrawing groups, or electron-donating groups.

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Tustin, CA, United States of America

Christine R Xu