Mayo Foundation for Medical Education and Research

University of Leeds

Christine Marie Pulido

Jose S Pulido

Richard G Vile

Peter Selby

Timothy J Kottke

Alan A Melcher

Jill M Thompson

Rosa Maria Diaz

This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-11a antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.

Methods and materials for treating cancer

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Rochester, MN, United States of America

Christine Marie Pulido