Astrazeneca Ab

Christine Marie Paul Lambert

Patrick Ple

Laurent Francois Andre Hennequin

Graham C Crawley

Bernard Christophe Barlaam

Darren Mckerrecher

Jeffrey Philip Poyser

Benedicte Delouvrie

Craig Steven Harris

Justin Fairfield Bower

Gilles Ouvry

Jon James Gordon Winter

Gary Fairley

The invention concerns pyridine and pyrazine derivatives of Formula I or a pharmaceutically-acceptable salt thereof, wherein each of W, G, G, G, G, J, Ring A, n and Rhas any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.

Pyridine and pyrazine derivatives -083

The invention concerns the use of a quinazoline derivative of Formula (I) wherein Qincludes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q&#x2014;X&#x2014; wherein Xincludes a direct bond and O and Qincludes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of Rand Ris hydrogen or (1-6C)alkyl; Z includes O, S and NH; and Qincludes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human. 

Method of producing an antiangiogenic or vascular permeability reducing effect

The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R, n, Rand Rhave any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.

Quinazoline derivatives

The invention concerns quinazoline derivatives of Formula (I)wherein each of m, R, n, Rand Rhave any of the meanings defined in the description; process for the preparation, pharmaceutical compositions them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.

The invention concerns quinazoline derivatives of Formula Iwherein each of m, R, n, Rand Rhave any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.

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Reims, France

Christine Marie Paul Lambert