Dnax Research Institute of Molecular and Cellular Biology, Inc.

Johns Hopkins University

Christine L Martens

Kevin W Moore

Thomas F Huff

Kimishige Ishizaka

Plasmid vectors are provided that carry complementary DNA (cDNA) clones coding for polypeptides exhibiting mammalian IgE binding factor activity. One of these clones contains an open reading frame consisting of 556 codons. The cDNA is derived from messenger RNA isolated from a rat/mouse T-cell hybridoma line. The cDNA was cloned by incorporation into a pcD plasmid vector. The plasmid vector also contains DNA segments from the SV40 virus, permitting expression of the cDNA to form a polypeptide having IgE potentiating activity after transfection into a mammalian host cell, such as monkey Cos7 cells.

CDNA clones coding for polypeptides exhibiting IGE binding factor

Immunosuppressive peptides having glycosylation inhibiting factor activity are provided. The peptides include the following sequence and its homologs: ##STR1##

Growing community of inventors

Menlo Park, CA, United States of America

Christine L Martens