Dow Agrosciences LLC

Neurovive Pharmaceutical Ab

Wyeth

Biotica Technology Limited

The University of Oviedo

Dow Agroscienceas LLC

Buck Institute for Research on Aging

Abliva Ab

Christine Janet Martin

Barrie Wilkinson

Steven James Moss

Matthew Alan Gregory

Paul Richard Graupner

Clive Waldron

Paul Lewer

Lesley S Burns

William A Vousden

Peter Francis Leadlay

Steven Gary Kendrew

Jose A Salas

Carmen Mendez

Alfredo F Brana

Marko Oliynyk

Barnie Wilkinson

Carlos Olano

Cesar Sanchez

Paul R Graupner

Lesley S Sheehan

There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.

Sanglifehrin derivatives and methods for their production

The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning into produce the spinosyns, and methods of controlling insects using the spinosyns.

Spinosyn-producing polyketide synthases

There are provided inter alia compounds of formula (I) useful as cyclophilin inhibitors.

Sanglifehrin based compounds

The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.

Production of polyketides and other natural products

The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials and methods including enzyme systems, nucleic acids, vectors and cells are provided for the preparation of polyketides including borrelidin and analogues and derivatives thereof. Novel polyketide molecules are also provided.

Borrelidin-producing polyketide synthase and its use

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Cambridge, United Kingdom

Christine Janet Martin