Pharmacia & Upjohn Ab

Advanced Polymer Systems, Inc.

Medennium, Inc.

Christine J Liau

Stephen Q Zhou

Michael Froix

Christopher D Wilcox

Peter P Huo

Larry W Shipley

Sok L Khor

Hien Nguyen

Sverker Norrby

Igor Valyunin

Intraocular lenses containing a photochromic agent, are disclosed. Specifically, the foldable intraocular lens of the present invention comprises an optic body made from a crosslinked material comprising at least one monomer, a crosslinker, a UV absorber, and a photochromic agent which has a maximum absorption peak of about 400-500 nm in its excited state. The lens has a glass transition temperature of about 37&#xb0; C. or lower. Methods for making these intraocular lenses are also taught.

Photochromic intraocular lenses and methods of making the same

Ophthalmic devices suitable for implantation into the eye through small incisions are disclosed. These devices are made from a composition comprising crystalline or semi-crystalline polymeric materials which have a glass transition temperature (T ) of from about &minus;100&deg; C. to about 20&deg; C., a melting point temperature (T ) of from about 0&deg; C. to about 37&deg; C., and wherein T for the material is lower than T for the composition. Disclosed devices include intraocular lenses, corneal inlays, ocular drug delivery devices and implants for reducing intraocular pressure in glaucoma patients; intraocular lenses are preferred.

Crystalline polymeric compositions for ophthalmic devices

An injectable intraocular lens composed of a silicone material is disclosed. The silicone lens material is polymerized from a plurality of siloxane monomers. The silicone lens material has a specific gravity great than 1.0 and a refractive index of a natural lens.

Injectable intraocular lens

Reduced trauma medical implants and methods for their use are disclosed wherein at least a portion of the implant is formed of a stretch-crystallizable elastomeric material formulated to exhibit the property of stretch crystallization upon substantial elongation of the implant to form stable, small-incision implant configurations having at least one dimension substantially reduced for insertion through a surgical incision that is small relative to the incision size necessary to implant the unstretched implant. Exemplary embodiments include intraocular implants formed of optically clear, high refractive index stretch-crystallizable silicone elastomers formulated to stretch crystallize at near ambient temperatures upon elongations greater than or equal to 300% and to recover their original configuration immediately upon exposure to body temperature following implantation.

Medical implants of stretch-crystallizable elastomers and methods of

An apparatus for dispensing pressurized material is comprised of a container, a polymeric matrix having a network of macropores located within the container, and a propellant that may be reversibly sorbed with the network of macropores so as to desorb as the partial pressure of the propellant within the container decreases. The network of pores is substantially non-swellable upon sorption and desorption of the propellant during filling and use of the dispensing apparatus. The polymeric matrix may comprise aggregates of macroporous polymeric particles in which the particles define a substantially non-collapsible pore network and the aggregates define interstitial spaces between the particles, and the interstitial spaces are substantially larger than the pore network.

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Irvine, CA, United States of America

Christine J Liau