Just-evotec Biologics, Inc.

Beth Israel Deaconess Medical Center, Inc.

The Rockefeller University

Christine C Siska

Bruce A Kerwin

Alison J Gillespie

Julee A Floyd

Randal Robert Ketchem

Rutilio Clark

Dan H Barouch

Jeremy M Shaver

Michel Nussenzweig

Richard S Rogers

Featured are PGDM1400 variant antibodies or fragments thereof, which can be administered, e.g., as antibody therapies for treating human immunodeficiency virus (HIV) infection. In particular, featured are methods of treating or curing subjects infected with HIV and/or preventing HIV infections in subjects at risk of HIV transmission using the PGDM1400 variant antibodies or fragments thereof.

Antibody therapies for human immunodeficiency virus (HIV)

The present disclosure provides optimized broadly-neutralizing anti-HIV antibodies, having modified light chain variable regions and/or heavy chain variable regions leading to improved biophysical characteristics. The present disclosure also provides methods for producing these anti-HIV antibodies and methods of use thereof.

Anti-HIV antibody 10-1074 variants

Ophthalmic formulations comprising aflibercept and a lysine salt tonicifying agent are disclosed that are suitable for a method of treatment of an eye disorder or disease by intravitreal or topical administration.

Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof

Ophthalmic formulations comprising aflibercept are disclosed that are suitable for a method of treatment of an eye disorder or disease by intravitreal or topical administration.

Aflibercept formulations and uses thereof

Featured are PGT121 variant antibodies or fragments thereof, which can be administered, e.g., as antibody therapies for treating human immunodeficiency virus (HIV) infection. In particular, featured are methods of treating subjects infected with HIV and/or blocking HIV infections in subjects at risk of HIV transmission using the PGT121 variant antibodies or fragments thereof.

Growing community of inventors

Seattle, WA, United States of America

Christine C Siska