The University of North Carolina at Chapel Hill

Florida State University Research Foundation, Inc.

Duke University

Auburn University

Other

The University of North Carolina at Charlotte

Christine C Dykstra

Richard Ray Tidwell

David W Boykin

W David Wilson

John R Perfect

James E Hall

Arvind Kumar

Kenny V Brock

Chad F Stephens

Arvid Kumar

Maurice Daniel Givens

David A Stringfellow

Byron L Blagburn

Bijan P Das

Jaroslaw Spychala

Ronald I Swanstrom

James C Hudson

Sandra Ewald

The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection

The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)&#x2013;(VI) as recited throughout the application.

Disclosed is a method of inhibiting retroviral integrase in a subject in need of such treatment. The method comprises administering to the subject an effective retroviral integrase inhibiting amount of a bis-benzimidazole compound such as bis&lsqb;5-amidino-2-benzimidazolyl&rsqb;methane, 1,2-bis&lsqb;5-amidino-2-benzimidazolyl&rsqb;ethane, 1,2-bis&lsqb;5-amidino-2-benzimidazolyl&rsqb;ethene or a pharmaceutically acceptable salt thereof. A method for combatting retroviral infections is also disclosed.

Method of inhibiting retroviral integrase

In one aspect, the invention relates to a method of treating infectious bursal disease (IBD) in an avian subject in need of such treatment. The method comprises administering to the subject a compound of the formulas (I) through (IV) or a pharmaceutically acceptable salt thereof in an amount sufficient to treat IBD. In another aspect, the invention relates to a method of producing active immunity against infectious bursal virus disease (IBD) in an avian subject. The method comprises administering to a subject an immunogenic-amount of an IBDV vaccine and a compound selected from the compounds of formulas (I) through (IV) described herein. The compound represented by formulas (I) through (IV) is administered in an amount sufficient to induce an immune response in the avian subject.

Methods and formulations for the treatment of infectious bursal disease in avian subjects

The present invention provides methods for treating,and,in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.

Methods of combatting infectious diseases using dicationic bis-benzimidazoles

The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.

Methods of combating infectious diseases using dicatoni

Methods of combatting infectious diseases using dicationic

Method of combatting infectious diseases using dicationic

Methods of combatting infectious disease using dicationic

The present invention provides methods for treating retroviral infection and methods of treating HIV infection. The methods of the present invention include administering compounds of the general Formula I: ##STR1## wherein L, R.sub.1, R.sub.2, R.sub.3, R.sub.4 are defined herein.

Methods of treating retroviral infection and compounds useful therefor

Method of combatting infectious diseases using dicatonic

Growing community of inventors

Chapel Hill, NC, United States of America

Christine C Dykstra