Beth Israel Deaconess Medical Center, Inc.

Triad National Security, LLC

Christine Bricault

Dan H Barouch

Bette T Korber

Karina Yusim

The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).

Signature-based human immunodeficiency virus (HIV) envelope (Env) trimer vaccines and methods of using the same

The invention features stabilized human immunodeficiency virus (H IV) clade C envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV clade C Env trimers. In addition, the invention features methods of making and using the stabilized HIV clade C Env trimers of the invention.

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Boston, MA, United States of America

Christine Bricault