Agilent Technologies, Inc.

Hewlett-packard Company

Christine A Miller

Steven Michael Fischer

Paul C Goodley

James Alexander Apffel, Jr

Patrick D Perkins

Harry F Prest

Kristin Briana Bernick

Genevieve Van De Bittner

Nora W Gee

Reagents and methods for extracting and stabilizing metabolites at room temperature and methods in which metabolites and one or more of proteins, lipids and nucleic acids are extracted from a single sample in a unified workflow.

Room temperature methods for preparing biological analytes

The present invention provides, inter alia, apparatuses and methods for ionizing samples that are in gaseous phase or can be vaporized/sublimated. The samples include samples to be analyzed and mass calibrants that serve as standards. In addition, the present invention also provides calibrant formulations that release mass calibrants in a slow, controlled manner.

Apparatuses, methods and compositions for ionization of samples and mass calibrants

A method of analyzing a sample comprising multiple protein species is provided. The proteins are separated by species such that the multiple protein species emerge in a sequential order and are then digested in the sequential order in which they emerge from the separation process. The digested proteins are introduced into a mass spectrometer in the same sequential order so that, within a given time window, the digested proteins introduced into the mass spectrometer are covariant.

Linear high-throughput proteomics

Method for identifying low charge, low weight ions with multiple charge states in mass spectrographic analysis. Ions are matched to a charge series by testing peak width, isotope spacing, and isotope ratios, using instrument resolution and information derived from the instrument spectrum. By following these tests erroneous assignment of ions to a series are avoided, providing higher quality data to the user.

Growing community of inventors

Campbell, CA, United States of America

Christine A Miller