Los Angeles Biomedical Research Institute at Harbor-Ucla Medical Center

Christina Wang

YanHe Lue

Ronald S Swerdloff

Provided herein are compositions, methods and uses of humanin or a humanin analog, for example, in treating a subject with humanin or a humanin analog, in part, to reduce, decrease, or inhibit cardiotoxicity caused or induced by an anti-cancer or anti-tumor therapeutic agent, or to protect or preserve cardiac function in the presence of an anti-tumor or anti-cancer therapeutic agent. In some aspects, humanin or humanin analogs, alone or in combination with another cardioprotective agent such as Dexrazoxane are used in combination with a chemotherapeutic agent to treat a hyperproliferative disease or disorder.

Methods for reducing cardiotoxicity from chemotherapy by administering humanin analog compositions

Described herein are methods of enhancing chemotherapeutic treatment of a hyperproliferative disorder by, in part, administering a composition comprising one or more humanin polypeptides to a subject receiving chemotherapy.

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Long Beach, CA, United States of America

Christina Wang