Basf Agricultural Solutions Seed US LLC

Christina Thies

Jan Tebbe

Fabien Poree

Bernd Laber

Gudrun Lange

Michael Strerath

Ernst Weber

Manuel Dubald

Marc Linka

Wayne Coco

Nina Wobst

Nikolaus Pawlowski

Sandra Geske

Heike Balven-Ross

In the present invention, HPPD polypeptides and plants containing them showing a full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes are described. A set of mutant HPPD polypeptides have been designed which have either no or only a significantly reduced affinity to HPPD inhibitor herbicides and, at the same time, the rate of dissociation of the HPPD inhibitors of the mutant HPPD polypeptide is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding mutant HPPD polypeptides conferring tolerance to HPPD inhibitor herbicides belonging to various chemical classes are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.

HPPD variants and methods of use

Growing community of inventors

Dormagen, Germany

Christina Thies