Agency for Science, Technology and Research

National University of Singapore

Sony Corporation

Maritime and Port Authority of Singapore

Singapore Health Services Pte Ltd

Christina Li Lin Chai

Han Hong

Daniel Rittschof

Serina Siew Chen Lee

Gary Howard Dickinson

Serena Lay Ming Teo

Brendan Adrian Burkett

Takehisa Ishida

Steve Oh

Sunil Madhukar Bhangale

William Ying Khee Hwang

Xiaogang Yang

Yeap Hung Ng

Filip Laco

Qixing Zhong

Parappuveetil Sarangadharan Suresh

Joo Leng Low

Yoong Kim

Andreas Fechtenkotter

Sudipto Bari

Gigi Ngar Chee Chiu

This invention relates to a method for inducing or enhancing the differentiation of pluripotent stem cells into cardiomyocyte via casein kinase 1 inhibition said method comprising culturing the stem cells in the presence of a medium comprising a casein kinase 1 inhibitor of the formula (I) or (II) or a stereoisomer, tautomer, or a salt thereof wherein R, Rand Rindependently from another represent hydrogen, optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, heteroaryl or aryl; X represents NR, O or S; and Rrepresents hydrogen, optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, heteroaryl or aryl. The method can be used in the late phase of stem cell differentiation and in the compounds of formula (I) or (II) in combination with other small molecules can lead to especially high differentiation of stem cells into cardiomyocytes. The invention further relates to novel compounds which can be used in the method of the invention and kits for stem cell differentiation. 

2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis

The present invention relates to derivatives of &#x3b1;, &#x3b1;-disubstituted amide compounds which comprise a substituted aryl at the &#x3b1; carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation n a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, esters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalized so as to include or be formed from the substituted compound can be used to reduce settlement.

Functionalised antifouling compounds and use thereof

Disclosed is a process for preparing fluorinated core-shell polymer particles in which the core is a non-fluorinated polymer and the shell is derived from at least 50% by weight of fluorinated monomers, by 1) synthesizing a core polymer latex by aqueous emulsion polymerization of non-fluorinated monomers forming the core polymer, 2) adding the shell-forming fluorinated monomers or mixtures of at least 50% by weight of fluorinated monomers with non-fluorinated monomers to the core polymer latex of step 1) and allowing for at least one hour of equilibration time in which essentially no polymerization of the shell monomers occurs, 3) reacting the shell-forming monomers in the mixture from step 2) to form the core-shell polymer particles, wherein the process steps 1) to 3) are carried out under mechanical stirring in the absence of surfactants, emulsifiers, emulsifying monomers and mixtures thereof.

Fluorinated core-shell-polymers and process for preparing same

The present invention relates to derivatives of &#x3b1;,&#x3b1;-disubstituted amide compounds which comprise a substituted aryl at the &#x3b1; carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation in a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, esters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalized so as to include or be formed from the substituted compound can be used to reduce settlement.

A ferroelectric film comprising polyaminodifluoroborane (PADFB). Also a memory device utilizing the ferroelectric film, a method of fabricating a ferroelectric polymer and a ferroelectric solution.

Ferroelectric polymer

Growing community of inventors

Singapore, Singapore

Christina Li Lin Chai