10x Genomics, Inc.

Christina Galonska

Marlon Stoeckius

Layla Katiraee

Caroline Julie Gallant

James Michael Chell

Jonathan Alles

Michael Schnall-Levin

Yifeng Yin

David Sukovich

Felice Alessio Bava

Jennifer Chew

Cedric Uytingco

Joseph Francis Shuga

Marco Mignardi

Octavian Marian Bloju

Patrick Roelli

Aleksandra Jurek

Ryo Hatori

Rapolas Spalinskas

Mesruh Turkekul

Anna-Maria Katsori

Malte Kühnemund

Denise Cheung

Naishitha Anaparthy

Ariel Royall

Alexander Hermes

Provided herein are methods, compositions, and kits for the spatial analysis of target nucleic acids, or complements thereof, by their 5' end.

Methods, compositions, and kits for determining the location of an analyte in a biological sample

Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.

Spatial analysis of epigenetic modifications

Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using DNA templated ligation. For example, provided herein are methods for detecting an gDNA analyte in a biological sample where (i) the first RTL probe and second RTL probe hybridize to adjacent sequences on the gDNA analyte, (ii) enzyme-mediate cleavage of a 5′ FLAP results in release of the 5′ FLAP, and (iii) the sequence of the 5′ FLAP is determined and used to detect the gDNA analyte in the biological sample.

Methods for spatial analysis using DNA capture

Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

Methods for spatial analysis using RNA-templated ligation

Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.

Multiplex capture of gene and protein expression from a biological sample

Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample.

Spatial analysis to detect sequence variants

Spatial analysis of DNA methylation

Growing community of inventors

Stockholm, Sweden

Christina Galonska