Boehringer Ingelheim Vetmedica Gmbh

Christiane Fetzer

Gregor Meyers

Martina Von Freyburg

Knut Elbers

Andreas Gallei

Stefan Pesch

Andreas Ege

The present invention belongs to the field of animal health and relates to a nucleic acid sequence which comprises the genome of an infectious genotype I (EU) PRRS virus clone useful for studying Porcine Reproductive and Respiratory Syndrome (PRRS), a viral disease affecting swine, and in the development of vaccines, therapeutics and diagnostics for the prophylaxis, treatment and diagnosis of PRRS.

Infectious CDNA clone of european PRRS virus and uses thereof

The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.

Infectious bovine viral diarrhea virus

Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Eand at least another mutation in the coding sequence for Nwhich preferably leads to combined inactivation of the RNase activity residing in glycoprotein Ein addition to the inactivation of the (hypothesized) immunomodulating activity residing in N. Methods for attenuating pestiviruses such as BVDV, nucleic acids encoding the pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV, of the invention.

Vaccine comprising an attenuated pestivirus

The present invention is related to improved modified live PRRS vaccines of European genotype and new PRRSV strains which can be used for the manufacture of such vaccines.

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Tuebingen, Germany

Christiane Fetzer