Glaxosmithkline Biologicals Sa

Christian Van Hoecke

Moncef Mohamed Slaoui

Nathalie Garcon

The invention relates to methods for one-dose influenza vaccine for intradermal delivery of a trivalent, non-live influenza antigen preparation, particularly a split influenza preparation.

Methods for one-dose intradermal delivery for non-live trivalent influenza vaccine

The invention relates to the use of a trivalent, non-live influenza antigen preparation, particularly a split influenza preparation, in the manufacture of a one-dose influenza vaccine for intradermal delivery. In particular, the invention relates to the use of split influenza preparations wherein the vaccine comprises at least one non-ionic surfactant selected from the group consisting of the octyl-or nonylphenoxy polyoxyethanols (for example the commercially available Triton&#x2122; series), polyoxyethylene sorbitan esters (Tween&#x2122; series) and polyoxyethylene ethers or esters of general formula (I): HO(CHCHO)-A-R, wherein n is 1-50, A is a bond or &#x2014;C(O)&#x2014;, R is Calkyl or phenyl Calkyl; and combinations of two or more of these.

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Rixensart, Belgium

Christian Van Hoecke