Boehringer Ingelheim International Gmbh

Christian Smethurst

Harald Engelhardt

Davide Gianni

Ulrich Reiser

Andreas Mantoulidis

Dirk Kessler

Laetitia Martin

Andreas Steffen

Disclosed are compounds of the formula (I) wherein the groups Rto Rhave the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

Triazolopyrazine

Method for treating AML and MM by administration of a compound of the formula (I) wherein the groups Rto Rhave the meanings given in the specification.

Substituted [1,2,4]triazolo[4,3-a]pyrazines as BRD4 inhibitors

Disclosed are compounds of general formula (I) wherein the groups Rto Rhave the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

Triazolopyridazine

The present invention encompasses compounds of general formula (I) wherein the groups Rto Rand Xthrough Xhave the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

Pyridinones

Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors

The present invention encompasses compounds of general formula (I) wherein the groups Rto Rand Ato Ahave the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

Dihydroquinazolinone analogues

The present invention encompasses compounds of general formula (I) wherein the groups Rto R, Aand Ahave the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

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Vienna, Austria

Christian Smethurst